University of Potsdam
Institute of Mathematics
Science Park Golm
Karl-Liebknecht-Str. 24/25
D-14476 Potsdam Golm
email: alexander.solms@uni-potsdam.de
Phone: +49 (0)331 / 977 5948
Fax: +49 (033)1 / 977 1045
I am a mathematician specialised in stochastic approaches and statistics. Moreover, I always had a big interest in medical sciences and looked for a discipline where to combine these two areas. I naturally focused on biostatistics which led me towards the pharmacometrics speciality. The underlying mathematical methodology is very complex, especially the stochastic aspects of the pharmacokinetic modeling -i.e. the mixed effects approach- offers a wide range of interesting problems.
My main focus in the PharMetrX program is to determine how the observed variability in pharmacokinetic data can be explained by hierarchical models -i.e. the allocation of variability into inter-indivivdual, inter-occasion and residual variabilty- with the objective to give a mechanistic understanding of the resulting variance components. More specifically, the unknown random aspect of the inter-individual variability could be explained by deterministic elements such as covariates common to drugs presenting the same biopharmaceutical properties.
This would lead to a better understanding of the origins of the variability in pharmacokinetics data and would allow to optimise the study designs in drug development and the dosing regimen going towards dose indivisualization.
